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Allergens are things that can cause allergies. Most allergens are proteins, and some are part of something called a 'hapten,' which is a small molecule that can make your immune system react when it's attached to a bigger carrier. Haptens can't cause allergies on their own. They need to attach to a carrier protein in your body to trigger an allergic reaction.
Instead of using specific proteins made in a lab (single sequence) in the usual testing method, Synoida came up with the 'total allergen protein purification' technique. This method involves checking each protein to make sure no potential allergens are missed, reducing the chance of causing allergies.
We use molecular biology and proteomics techniques to create different ways to purify each protein based on its characteristics. Thanks to these methods, Synoida now has nearly 100 types of common allergen proteins. These include common inhalation allergens like mites, pollens, and animal fur, as well as everyday ingestion allergens like seafood, nuts, and milk.
FLISA: Fluorescence-Linked Immuno-Sorbent Array
Microarray protein chip: The foundation of the Synoida microarray protein chip is based on using protein as probe markers which are spotted on the surface of a glass slide.
To perform the test, serum sample is added to the test area creating an antigen-antibody binding reaction. A secondary antibody with fluorescent dye is then added to the surface allowing for specific wavelengths of the laser scanner to pin-point the specific antibodies induced by allergic reactions. Finally, three different concentrations of standard reagent are used to calculate the actual values and distributed over a standard curve to produce an accurate result.
BioDot Spotting system
Our allergen protein chip uses the BioDot Spotting system. This system uses a programmable robotic arm with a three-dimensional axis and specialized slit needles (using the “Siphon Theory”) to transfer the allergens onto the spotting surface.
Allergy scanning system
Synoida IgE/G Allergy Tests employ the Axon 4100B laser scanner. This scanner uses a specific wavelength to excite a fluorescence dye attached to a secondary antibody, producing a distinct signal. The AxSyssoftware is then utilized to analyze these fluorescence signals, generating a quick and easy-to-read report.
In contrast to traditional ELISA (Enzyme-linked immune-sorbent assay) allergy analysis, Synoida'sallergy testing platform is streamlined with an innovative semi-automatic scanner and analysis software.
The platform offers several advantages:
1. Minimal Serum Usage: A smaller amount of serum sample is required.
2. Stability and Sensitivity: We perform triplicate tests on each chip to ensure batch stability, and our system can detect concentration limits down to the "pg" grade.
3. Environmentally-friendly and Cost-effective: The test requires a small amount of reagents and consumables, reducing resource consumption.
4.High Efficiency: Multiple samples can be processed simultaneously, and results are available within 1-2 hours.
5. High Flexibility: The FLISA platform allows for increased flexibility in test items. As the number of test items grows, the required amount of serum sample and reagents can remain unchanged.